منابع مشابه
Delayed aggregation of proteoglycans in adult human articular cartilage.
The biosynthesis and macromolecular organization of proteoglycans was studied in explants of adult human articular cartilage. In a series of pulse-chase experiments, labelling with (35S)sulphate, it was shown that the proteoglycan monomer is synthesized as a precursor that has a low affinity for hyaluronic acid. These findings suggest a possible mechanism by which the rate of incorporation of p...
متن کاملCartilage proteoglycans.
The predominant proteoglycan present in cartilage is the large chondroitin sulfate proteoglycan 'aggrecan'. Following its secretion, aggrecan self-assembles into a supramolecular structure with as many as 50 monomers bound to a filament of hyaluronan. Aggrecan serves a direct, primary role providing the osmotic resistance necessary for cartilage to resist compressive loads. Other proteoglycans ...
متن کاملProteoglycans of Hyaline Cartilage
Proteoglycan monomers from guinea-pig costal cartilage, bovine nasal and bovine tracheal cartilage were observed in the electron microscope after being spread in a monomolecular layer with cytochrome c. The proteoglycan molecule appeared as an extended central core filament to which side-chain filaments were attached at various intervals. The molecules from the three sources displayed great ult...
متن کاملProteoglycans of cartilage.
Proteoglycans are probably the most important nonfibrillar constituents of connective tissue although little is known about the proteoglycans of connective tissue other than cartilage. Hence this paper is mainly concerned with cartilage proteoglycans. Proteoglycans are found throughout connective tissue, but those of cartilage have certain features that distinguish them from proteoglycans of ot...
متن کاملHierarchical organization of cartilage proteoglycans.
The hierarchical organization of cartilage proteoglycans is investigated on different length and time scales using osmotic pressure measurements, small angle neutron scattering (SANS), small angle X-ray scattering (SAXS), static and dynamic light scattering and neutron spin echo techniques. Osmotic pressure measurements reveal association of aggrecan bottlebrushes into microgel-like assemblies....
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1974
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)42509-x